Intervention Strategy Search
Search intervention scripts on calibrated + UQ models.
Outputs are mechanism-comparison intervention_script.yaml files — not molecular structures and not dosing advice. Bind model version and UQ; report robustness, not a single “optimum”.
§ 1
Problem framing
Under a scenario and COU constraints, search timing/intensity combinations that improve key endpoints while evaluating brittleness on UQ samples.
v1 prioritizes the virus scenario; other scenarios reserve the same interfaces.
§ 2
Objective & constraints (sketch)
Formulas live in task files and follow COU; structure example only.
search_task.yaml
objective:
primary: T_clear
sense: minimize
constraints:
- name: inflammation_AUC
op: "<="
value_ref: "COU.bounds.inflammation"
robustness:
require_uq_model: true
report: ["median", "worst_decile_placeholder"]§ 3
Search pipeline
- 01
Lock model version
Only calibrated versions with UQ reports.
- 02
Define search space
Timing, dose tiers, combination rules — all auditable.
- 03
Optimize / sample
Black-box optimization or stratified sampling akin to calibration tooling.
- 04
UQ robustness
Replay Top-K on posterior/ABC samples; report distributions.
- 05
Export scripts
Top-K intervention_script.yaml + audit fields.
§ 4
Artifacts
- intervention_script.yaml (Top-K)
- search_report.json (settings & constraints)
- robustness_summary (no measured numbers yet)
§ 5
Disclaimer
Strategy-search outputs are for mechanism comparison and research demos only. Not medical advice, diagnosis, treatment or dosing guidance; not for any individual patient.